6 Benefits of Hyaluronic Acid

Written by Dr. Bal Krishna Subedi

Orthopedic Surgeon

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August 27, 2020

Hyaluronic Acid: It’s Health Benefits

Hyaluronic acid (HA) is an essential component of the extracellular matrix and is found in the highest concentration in the joints, eyes, and skin [1]. Its main function is to retain water and keep body tissues hydrated. Its use in the medical field as a supplement has been growing, and hyaluronic acid is now available as oral supplements, injectable forms, eye drops, and topical serums.

Here are 6 Scientific Research-Based Benefits of HA:

1.) Osteoarthritis

HA is an important component of the body’s synovial fluid and keeps the space between joints well lubricated, preventing them from grinding against each other.
Oral supplements of HA have also been found to decrease pain and significantly improve joint function in patients with knee osteoarthritis [2]. A meta-analysis also found that there is a real benefit from an intra-articular injection of HA in patients with knee osteoarthritis [3].

2.) Aging Skin

Oral intake of HA was found to significantly increase skin hydration and elasticity, while reducing skin dryness and wrinkle depth [4].

3.) Dry Eyes

HA used as tear substitute drops can change the tear environment and improve epithelial conditions of the ocular surface, thus preventing dry eyes [5]. It is also being used in various eye operations like cataract surgery.

4.) Acid Reflux and Heartburn

HA may help protect the esophageal lining and soothe symptoms of heartburn in patients with acid reflux disease [6].

5.) Speeds Wound Healing

HA may be beneficial in minimizing bacterial contamination of surgical wounds [7] and may help wounds heal faster.

6.) Preserves Bone Strength

While its effects on human bone health have not been studied, studies in rats have shown oral HA inhibits bone resorption and increases bone density [1].

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References:

1.) Stancíková M, Svík K, Istok R, Rovenský J, Velebný V. The effects of hyaluronan on bone resorption and bone mineral density in a rat model of estrogen deficiency-induced osteopenia. Int J Tissue React. 2004;26(1-2):9-16.

2.) Nelson F, Zvirbulis R, Zonca B, Li K, Turner S, Pasierb M et al. Erratum to: The effects of an oral preparation containing hyaluronic acid (Oralvisc®) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. 2020.

3.) Richette P, Chevalier X, Ea H, Eymard F, Henrotin Y, Ornetti P et al. Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias. 2020.

4.) Göllner I, Voss W, von Hehn U, Kammerer S. Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study. Journal of Evidence-Based Complementary & Alternative Medicine. 2017;22(4):816-823.

5.) Iester M, Orsoni G, Gamba G, Taffara M, Mangiafico P, Giuffrida S et al. Improvement of the ocular surface using hypotonic 0.4% hyaluronic acid drops in keratoconjunctivitis sicca. Eye. 2000;14(6):892-898.